Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Combined Effects of Drugs: Synergism01:27

Combined Effects of Drugs: Synergism

4.5K
Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
4.5K
Factors Affecting Renal Clearance: Drug Distribution and Drug Interactions01:09

Factors Affecting Renal Clearance: Drug Distribution and Drug Interactions

213
Renal clearance plays a pivotal role in drug elimination from the body and can be influenced by drug distribution and interactions. Understanding these factors is crucial in pharmacology as they impact the effectiveness and duration of drug therapy.
One important factor is the relationship between renal clearance and the apparent volume of distribution. Renal clearance tends to be inversely proportional to the apparent volume of distribution. Drugs with an extensive distribution volume or those...
213
Antibiotic Selection00:57

Antibiotic Selection

55.0K
Overview
55.0K
Antimicrobial Effectiveness01:28

Antimicrobial Effectiveness

135
The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
135
Clearance Models: Compartment Models01:25

Clearance Models: Compartment Models

118
Clearance measures drug elimination from the central compartment, including plasma and highly perfused organs like kidneys and liver. Its calculation varies depending on pharmacokinetic models and administration routes. The one-compartment model, for instance, portrays the pharmacokinetics of polar drugs such as aminoglycoside antibiotics administered intravenously and readily excreted in urine. In this case, clearance is influenced by the terminal rate constant (λz) and the total volume...
118
Urine Studies II: Urine Culture and Sensitivity Test01:26

Urine Studies II: Urine Culture and Sensitivity Test

98
A urine culture and sensitivity test is a diagnostic procedure used to identify urinary tract bacterial infections and determine the most effective antibiotics for treatment. This test is generally preferred when a patient shows manifestations of a urinary tract infection, such as frequent or painful urination, cloudy or foul-smelling urine, or lower abdominal pain.Purpose of the TestThe primary goals of a urine culture and sensitivity test are to:Determine the specific bacteria causing the...
98

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Non-canonical gene amplifications facilitate adaptive evolution in bacteria.

Nature microbiology·2026
Same author

GplR1, an unusual TetR-like transcription factor in <i>Mycobacterium abscessus,</i> controls the production of cell wall glycopeptidolipids, colony morphology, and virulence.

mSystems·2025
Same author

Induction-free recombineering for simple targeted gene-deletions in various mycobacteria.

Microbiology spectrum·2025
Same author

De novo mutations mediate phenotypic switching in an opportunistic human lung pathogen.

Nature communications·2025
Same author

GplR1, an unusual TetR-like transcription factor in <i>Mycobacterium abscessus,</i> controls the production of cell wall glycopeptidolipids, colony morphology, and virulence.

bioRxiv : the preprint server for biology·2025
Same author

Exploring the principles behind antibiotics with limited resistance.

Nature communications·2025

関連する実験動画

Updated: Aug 26, 2025

Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method
12:03

Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method

Published on: April 18, 2019

26.5K

抗生物質の組み合わせは,Staphylococcus aureusのクリアランスを減少させる

Viktória Lázár1,2,3, Olga Snitser1, Daniel Barkan4

  • 1Faculty of Biology, Technion-Israel Institute of Technology, Haifa, Israel.

Nature
|October 5, 2022
PubMed
まとめ
この要約は機械生成です。

バクテリア感染に対する薬剤の組み合わせは,単一の薬剤よりも長期的なクリアランスには効果が低く,時には治療を阻害します. 成長しない細菌をターゲットにすることで この抑制を克服し 耐性のある治療法を開発できます

さらに関連する動画

Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations
11:15

Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations

Published on: July 24, 2021

4.8K
Antibiotic Efficacy Testing in an Ex vivo Model of Pseudomonas aeruginosa and Staphylococcus aureus Biofilms in the Cystic Fibrosis Lung
09:26

Antibiotic Efficacy Testing in an Ex vivo Model of Pseudomonas aeruginosa and Staphylococcus aureus Biofilms in the Cystic Fibrosis Lung

Published on: January 22, 2021

7.1K

関連する実験動画

Last Updated: Aug 26, 2025

Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method
12:03

Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method

Published on: April 18, 2019

26.5K
Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations
11:15

Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations

Published on: July 24, 2021

4.8K
Antibiotic Efficacy Testing in an Ex vivo Model of Pseudomonas aeruginosa and Staphylococcus aureus Biofilms in the Cystic Fibrosis Lung
09:26

Antibiotic Efficacy Testing in an Ex vivo Model of Pseudomonas aeruginosa and Staphylococcus aureus Biofilms in the Cystic Fibrosis Lung

Published on: January 22, 2021

7.1K

科学分野:

  • 微生物学
  • 薬理学について
  • 感染症

背景:

  • 抗生物質耐性は 世界的な健康上の脅威となり 併用療法への関心が高まっています
  • 薬剤の組み合わせは,成長抑制のために研究されているが,臨床濃度での長期的な細菌クリアランスへの影響はあまり理解されていない.

研究 の 目的:

  • Staphylococcus aureusに対する抗生物質の組み合わせの長期クリアランスの有効性を体系的に定量化する.
  • 薬の相互作用が細菌の生存と耐性開発にどのように影響するかを調査する.

主な方法:

  • 長期にわたる抗生物質の組み合わせによる生存を評価するために,大量マイクロプレッティングと自動画像分析を使用した.
  • 14種類の抗生物質のペアの定量化された成長阻害,早期殺死,および長期の集団クリアランス.

主要な成果:

  • クリアランスの相互抑制が観察され,併用薬は個々の薬よりも効果が低い.
  • 増殖抑制と早期殺菌とは異なり,クリアランスの有効性が低下した.
  • 成長しないパーシスターを標的とした薬は抑制効果を回避した.
  • メチシリン耐性黄金球菌 (MRSA) に対しても,耐性に対して選択された組み合わせです.

結論:

  • 薬剤の組み合わせによる長期クリアランスの相互作用は,成長抑制効果と有意に異なる.
  • マルチドラッグの投与は,クリアランスの抑制作用により,効果が低下する可能性があります.
  • 耐性菌を標的とし クリアランスのダイナミクスを理解することは 効果的な抗生物質治療の設計に不可欠です