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Updated: Aug 26, 2025

A Novel Feeder-free System for Mass Production of Murine Natural Killer Cells In Vitro
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A Novel Feeder-free System for Mass Production of Murine Natural Killer Cells In Vitro

Published on: January 9, 2018

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STING誘発の調節性B細胞は,がん免疫におけるNK機能を損なう

Sirui Li1,2,3, Bhalchandra Mirlekar1,2, Brandon M Johnson1,3

  • 1Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Nature
|October 5, 2022
PubMed
まとめ

インターフェロン遺伝子刺激剤 (STING) アゴニストは,調節性B細胞を拡張し,抗腫瘍免疫を阻害する. B細胞におけるこのSTING- IL-35経路を標的にすることで,自然殺人細胞の反応を強めることで,がん治療が改善される可能性があります.

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