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Updated: Aug 26, 2025

Evaluation of LC3-II Release via Extracellular Vesicles in Relation to the Accumulation of Intracellular LC3-positive Vesicles
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Evaluation of LC3-II Release via Extracellular Vesicles in Relation to the Accumulation of Intracellular LC3-positive Vesicles

Published on: October 18, 2024

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2つのFTD-ALS遺伝子は,TDP-43の病変と変異を誘導するエンドソーマル経路に収束する

Wei Shao1, Tiffany W Todd1, Yanwei Wu1

  • 1Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.

Science (New York, N.Y.)
|October 6, 2022
PubMed
まとめ

フロントテンポラル認知症とALSはC9orf72とTBK1遺伝子が関与しています. C9orf72の蓄積はTBK1を阻害し,神経変性およびTDP-43の病変性を悪化させる.

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