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Updated: Aug 26, 2025

Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography
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Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography

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パロキセチンまたはクエチアピンがオキシコドンと併用されたか,またはオキシコドン単独で投与されたか,ハイパーキャプニア時の換気に対する効果:ランダム化臨床試験

Jeffry Florian1, Rutger van der Schrier2, Victoria Gershuny1

  • 1Division of Applied Regulatory Science, Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland.

JAMA
|October 11, 2022
PubMed
まとめ

健康な成人の場合,オキシコドンと併用したパロキセチンは,呼吸運動を著しく低下させたが,クエチアピンはそうしなかった. この研究は,ある抗うつ薬とオピオイドを併用する潜在的なリスクを強調し,さらなる研究が必要である.

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