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Updated: Aug 25, 2025

Author Spotlight: THP-1 Macrophage Response to LPS/ATP — Unveiling the Pyroptosis, Apoptosis, and Necroptosis Spectrum
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Author Spotlight: THP-1 Macrophage Response to LPS/ATP — Unveiling the Pyroptosis, Apoptosis, and Necroptosis Spectrum

Published on: May 3, 2024

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バクテリアのフォスフォリピド・フォスファタゼは,ユビキチンを乗っ取ることで宿主ピロプトーシスを阻害する

Qiyao Chai1, Shanshan Yu2, Yanzhao Zhong1,3

  • 1CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.

Science (New York, N.Y.)
|October 13, 2022
PubMed
まとめ

Mycobacterium tuberculosisは,細胞膜を脱酸化することによって宿主炎症体- 炎症性の経路を阻害するためにPtpBを使用し,それによって免疫反応を回避します. PtpBの活性を妨害すると,免疫が強化され,病原体の生存率が低下します.

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