関連する実験動画

Updated: May 13, 2026

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates
09:12

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates

Published on: January 30, 2014

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SYKは神経変性疾患における神経保護性マイクログリア応答を調整する

Hannah Ennerfelt1, Elizabeth L Frost2, Daniel A Shapiro2

  • 1Center for Brain Immunology and Glia (BIG), Department of Neuroscience, University of Virginia (UVA), Charlottesville, VA 22908, USA; Neuroscience Graduate Program, UVA, Charlottesville, VA 22908, USA; Cell and Molecular Biology Graduate Training Program, UVA, Charlottesville, VA 22908, USA.

Cell
|October 18, 2022
PubMed
まとめ

チロシンキナーゼ (SYK) は,アルツハイマー病のモデルにおけるマイクログリア機能に不可欠である. その消去はアミロイドβの堆積と神経病理を悪化させ,SYKの神経保護の役割を強調する.

キーワード:
アルツハイマー病SYK についてアミロイドβ病気に関連したマイクログリア実験的な自己免疫性脳内炎マイクログリア多発性硬化症神経変性疾患神経免疫学ファゴサイトーシス

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