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Updated: Aug 24, 2025

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
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E3リガースアダプタは,C端の周期性イミド分解を標的とする

Saki Ichikawa1, Hope A Flaxman1, Wenqing Xu1

  • 1Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.

Nature
|October 19, 2022
PubMed
まとめ

C端の周期性イミドは,脳細胞 (CRBN) によって認識された新発見の生理学的デグロンである. この発見はタンパク質分解の 自然なメカニズムを明らかにし 標的型タンパク質分解のような 治療的な応用に影響を与えます

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