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Updated: Aug 24, 2025

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
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Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate

Published on: June 21, 2017

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イリジウム触媒による非対称なカスケードアライレーション/レトロクライゼン反応

Zhi-Yuan Yi1, Lu Xiao1, Xin Chang1

  • 1College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China.

Journal of the American Chemical Society
|October 20, 2022
PubMed
まとめ

新しいイリジウム触媒反応は,単純な前駆体からキラル3ヒドロキシメチルペンテナル誘導体を効率的に生成します. この方法は天然製品合成と薬剤発見のための 価値ある化合物への 汎用的な経路を提供します

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The Claisen rearrangement is a [3,3] sigmatropic rearrangement of allyl vinyl ethers to unsaturated carbonyl compounds. The rearrangement is a concerted pericyclic reaction proceeding via a chair-like transition state.
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Cycloadditions are one of the most valuable and effective synthesis routes to form cyclic compounds. These are concerted pericyclic reactions between two unsaturated compounds resulting in a cyclic product with two new σ bonds formed at the expense of π bonds. The [4 + 2] cycloaddition, known as the Diels–Alder reaction, is the most common. The other example is a [2 + 2] cycloaddition.
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