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ヒトSLC19A1による周期性ダイヌクレオチドと葉酸の認識

Qixiang Zhang1,2, Xuyuan Zhang1, Yalan Zhu3

  • 1CAS Key Laboratory of Infection and Immunity, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.

Nature
|October 20, 2022
PubMed
まとめ

サイクリック・ディヌクレオチド (CDN) と葉酸型の分子はSLC19A1によって輸送される. Cryo-EM構造は,CDNと葉酸/抗葉酸の結合メカニズムを明らかにし,トランスポーター機能と疾患変異を明らかにします.

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