高カルセミア: 概要
Marcella Donovan Walker1, Elizabeth Shane1
1Division of Endocrinology, Department of Medicine, Columbia University Irving Medical Center, Vagelos College of Physicians and Surgeons, New York, New York.
JAMA
|October 25, 2022
まとめ
症状のない高カルセミアは 混乱や昏睡のような重症症状を引き起こす可能性があります 主要な副甲状腺症と悪性腫瘍は一般的な原因であり,観察からバイフォスフォネートまで,個別の治療が必要である.
科学分野:
- 内分泌学
- 腎臓科
- 腫瘍学
背景:
- 高カルセミアは,無症状の軽度の症例から,神経学的および全身的な症状を持つ重度のプレゼンテーションまで,人口の約1%に影響します.
- 主要性副甲状腺症 (PHPT) と悪性腫瘍は高カルセミアの約90%を占め,他の原因は粒状性疾患,内分泌病,および特定の薬剤を含む.
結論:
- ハイパーカルセミアの効果的な管理は,特定の基礎病因を特定し,治療することにかかっています.
- 予後は著しく変化し,無症状PHPTは一般的に優れた見通しを持ち,悪性腫瘍の高カルセミアは生存率の低下と関連しています.
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