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関連する概念動画

Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

4.7K
Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
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The Parathyroid Glands00:59

The Parathyroid Glands

2.3K
The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
2.3K
Synthesis and Functions of Calcitonin00:51

Synthesis and Functions of Calcitonin

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Calcitonin, a vital polypeptide hormone, regulates calcium levels within body fluids. It is released by the parafollicular cells, also known as C cells, situated in the follicular epithelium of the thyroid gland. Calcitonin responds to fluctuations in blood calcium levels and the influence of gastrointestinal hormones like gastrin and cholecystokinin.
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
2.1K
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

2.8K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.8K
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

64
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
64
Renal Failure: Dose Adjustments01:11

Renal Failure: Dose Adjustments

141
In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
141

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A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
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高カルセミア: 概要

Marcella Donovan Walker1, Elizabeth Shane1

  • 1Division of Endocrinology, Department of Medicine, Columbia University Irving Medical Center, Vagelos College of Physicians and Surgeons, New York, New York.

JAMA
|October 25, 2022
PubMed
まとめ
この要約は機械生成です。

症状のない高カルセミアは 混乱や昏睡のような重症症状を引き起こす可能性があります 主要な副甲状腺症と悪性腫瘍は一般的な原因であり,観察からバイフォスフォネートまで,個別の治療が必要である.

科学分野:

  • 内分泌学
  • 腎臓科
  • 腫瘍学

さらに関連する動画

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
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Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

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Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation
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Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation

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A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
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Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
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Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation
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背景:

  • 高カルセミアは,無症状の軽度の症例から,神経学的および全身的な症状を持つ重度のプレゼンテーションまで,人口の約1%に影響します.
  • 主要性副甲状腺症 (PHPT) と悪性腫瘍は高カルセミアの約90%を占め,他の原因は粒状性疾患,内分泌病,および特定の薬剤を含む.

結論:

  • ハイパーカルセミアの効果的な管理は,特定の基礎病因を特定し,治療することにかかっています.
  • 予後は著しく変化し,無症状PHPTは一般的に優れた見通しを持ち,悪性腫瘍の高カルセミアは生存率の低下と関連しています.