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Updated: Aug 24, 2025

Assaying Protein Kinase Activity with Radiolabeled ATP
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エンドソームにおける非正規のβ-アドレナージ的活性化

Yonghoon Kwon1, Sohum Mehta1, Mary Clark1

  • 1Department of Pharmacology, University of California, San Diego, La Jolla, CA, USA.

Nature
|October 26, 2022
PubMed
まとめ

Gタンパク質結合受容体 (GPCR) 信号は,プラズマ膜ではなく,エンドソームからの細胞外信号調節キナーゼ (ERK) を活性化します. この空間的制御は,核ERKの活動を調節することによって,細胞増殖に影響を与えます.

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