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Updated: Aug 24, 2025

Do's and Don'ts of Cryo-electron Microscopy: A Primer on Sample Preparation and High Quality Data Collection for Macromolecular 3D Reconstruction
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SEA複合体の冷凍-EM構造

Lucas Tafur1, Kerstin Hinterndorfer1, Caroline Gabus1

  • 1Department of Molecular and Cellular Biology, University of Geneva, Geneva, Switzerland.

Nature
|October 26, 2022
PubMed
まとめ

SEA複合体 (SEAC) は栄養素を感知する成長調節体であり,冷凍-EMによって明らかにされたモジュール構造を有する. SEACATは,TORC1の調節に影響を与えるSEACITの直接的阻害剤ではなく,支架として作用する.

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Cryo-electron Microscopy01:28

Cryo-electron Microscopy

Conventional electron microscopy (EM) involves dehydration, fixation, and staining of biological samples, which distorts the native state of biological molecules and results in several artifacts. Also, the high-energy electron beam damages the sample and makes it difficult to obtain high-resolution images. These issues can be addressed using cryo-EM, which uses frozen samples and gentler electron beams. The technique was developed by Jacques Dubochet, Joachim Frank, and Richard Henderson, for...
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