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Gene Conversion02:08

Gene Conversion

9.9K
Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the recombination of sequences forms the molecular basis of genomic evolution. Random and non-random permutations of genomic sequences create a library of new amalgamated sequences. These newly formed genomes can determine the fitness and survival of cells. In bacteria, homologous and non-homologous types of recombination lead to the evolution of new...
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What is Genetic Engineering?00:49

What is Genetic Engineering?

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Overview
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Gene Therapy00:59

Gene Therapy

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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
25.7K
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

35.0K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
35.0K
Types of Genetic Transfer Between Organisms02:18

Types of Genetic Transfer Between Organisms

29.1K
Genetic transfer occurs when genetic information is passed from one organism to another. It occurs via two mechanisms: vertical gene transfer and horizontal gene transfer. Vertical gene transfer occurs when genetic information is transferred from one generation to the next, which happens much more frequently than horizontal gene transfer. Both sexual and asexual reproduction are forms of vertical gene transfer, where one or more organisms pass some or all of their genome onto their progeny.
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Genome Copying Errors02:46

Genome Copying Errors

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DNA replication is a well-evolved process that copies millions of base pairs with high fidelity during each cell division. Occasionally a wrong base or a long stretch of wrong bases may get added to the daughter strands. If the errors are left unchecked, cells might accumulate several mutations that might endanger their  survival. Therefore, the copying errors are checked and repaired at three levels.
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Updated: Aug 23, 2025

Generation of Genomic Deletions in Mammalian Cell Lines via CRISPR/Cas9
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Generation of Genomic Deletions in Mammalian Cell Lines via CRISPR/Cas9

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遺伝子を盗み 結果に直面する

Ricky Padilla Del Valle1, Richard N McLaughlin1

  • 1Pacific Northwest Research Institute, Seattle, WA, USA.

Science (New York, N.Y.)
|October 27, 2022
PubMed
まとめ
この要約は機械生成です。

ヒトのゲノムには ウイルスと戦うウイルスの遺伝子があります DNAに組み込まれている この古代の遺伝子要素は ウイルス感染から自然に守ってくれるのです

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Genetic Manipulation in Δku80 Strains for Functional Genomic Analysis of Toxoplasma gondii
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Genetic Manipulation in Δku80 Strains for Functional Genomic Analysis of Toxoplasma gondii

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Genetic Mapping of Thermotolerance Differences Between Species of Saccharomyces Yeast via Genome-Wide Reciprocal Hemizygosity Analysis
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Genetic Mapping of Thermotolerance Differences Between Species of Saccharomyces Yeast via Genome-Wide Reciprocal Hemizygosity Analysis

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Last Updated: Aug 23, 2025

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Genetic Mapping of Thermotolerance Differences Between Species of Saccharomyces Yeast via Genome-Wide Reciprocal Hemizygosity Analysis
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科学分野:

  • ゲノミクス
  • ウイルス学
  • 分子生物学

背景:

  • 人間のゲノムには多くの内生レトロウイルス要素 (ERV) が含まれています.
  • ERVのいくつかは家畜化され,宿主にとって有益な機能を獲得しました.
  • 多くのERVの進化的起源と機能的意義は不明である.

研究 の 目的:

  • ヒトゲノムに特化したウイルスの封筒遺伝子の存在と機能を調査する.
  • この遺伝子の抗ウイルス活性を調べるため

主な方法:

  • ウイルスの遺伝子を特定するためのヒトゲノム配列のバイオ情報分析.
  • ヒトの細胞に遺伝子の存在を確認するための発現分析
  • 関連するウイルスに対する抗ウイルス活性を試験するインビトロ検査.

主要な成果:

  • 古代のレトロウイルス祖先から派生した家畜化されたウイルスの封筒遺伝子がヒトゲノムで確認されました.
  • この遺伝子はヒトの細胞で発現し 細胞膜に局所する.
  • ウイルスの侵入と複製を阻害する重要な抗ウイルス活性を示した.

結論:

  • 人間のゲノムは,家畜のウイルス遺伝子から派生した機能的な抗ウイルス防御機構を持っています.
  • この発見は ウイルスと宿主の共進化に光を当てます
  • ドメスティケートされたウイルスの遺伝子は 新種の抗ウイルス治療の標的となる可能性がある.