毒素に誘発された防御反応のための腸から脳への軸
Zhiyong Xie1, Xianying Zhang2, Miao Zhao3
1National Institute of Biological Sciences, Beijing, China; Department of Psychological Medicine, Zhongshan Hospital, State Key Laboratory of Medical Neurobiology, Institute for Translational Brain Research, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China.
Cell
|November 2, 2022
まとめ
毒素によって引き起こされる 吐き気や嘔吐を制御する 特定の腸-脳回路を 発見しました これらの経路は,消化された毒素に対する防御反応に不可欠であり,ヴァーガル感覚ニューロンと背面ヴァーガル複合体 (DVC) のニューロンが関与しています.
科学分野:
- 神経科学
- 胃腸内科
- 毒理学について
背景:
- 脳は毒素を摂取した後に 吐き気や嘔吐などの 防御反応を調整します
- 毒素検出のメカニズムと 神経回路は ほとんど不明です
研究 の 目的:
- ネズミの毒素誘発防御行動を媒介する 神経回路を調査する
- 毒素の検知と反応に関与する特定の腸から脳への経路を特定する.
主な方法:
- 毒素誘発防御反応を研究するための新しいマウスモデルの開発.
- 分子と回路レベルの分析を使って 神経経路をマップする
- 嫌味と味覚回避を評価する行動分析
主要な成果:
- Htr3a+ ヴァガル感覚神経と Tac1+ 背面ヴァガル複合体 (DVC) ニューロンを含む腸-脳回路が特定されました.
- Tac1+ DVCニューロンはロストラル・ブントラル呼吸器群と 横側パラブラキアル核に投射され 独特の防御行動を誘導します
- これらの回路は細菌の毒素と ドクソルビシンのような化学療法薬の両方に 反応を媒介することを示しました
結論:
- この研究は 摂取した毒素を検出し 防御反応を起こすための 重要な神経回路を明らかにしています
- 食物中毒と化学療法に対する 防御反応の共有回路メカニズムを示唆しています
- 毒素に起因する病気の行動を理解し,潜在的に治療するための基礎を提供します.
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