イヌリンの繊維は,微生物由来の胆酸と2型炎症を促進する
Mohammad Arifuzzaman1,2,3, Tae Hyung Won4, Ting-Ting Li1,2,3
1Jill Roberts Institute for Research in Inflammatory Bowel Disease, Division of Gastroenterology and Hepatology, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY, USA.
腸内細菌を変化させ 胆汁酸を増やし 2型炎症を引き起こします これは食事と微生物群と 障壁の表面での免疫反応を結びつける 新しいメカニズムを強調しています
科学分野:
- 免疫学
- 微生物学
- メタボロミクス
背景:
- 食物繊維は短鎖脂肪酸を通して 抗炎症効果があります
- ほとんどの繊維食とその代謝産物の免疫調節作用は十分に理解されていません.
研究 の 目的:
- イヌリン繊維が腸内微生物と宿主の免疫反応に どう影響するか調べる
- イヌリン媒介の炎症に関与する特定の代謝物を特定する.
主な方法:
- マウスの微生物配列化と非標的代謝学
- 2型炎症マーカー (IL-33,先天性リンパ球,エオシノフィリア) の分析
- 胆酸投与,受容体消去,微生物群の植民を伴う実験
主要な成果:
- イヌリンはマウスの微生物群の組成を変化させ,胆酸,特にホリック酸を増加させた.
- 腸と肺の2型炎症を引き起こしました
- コリック酸はイヌリンの効果を模倣し 胆酸受容体を遮断すると 効果が低下します
- イヌリンの効果は微生物群に依存し,アレルゲン/ヘルミントによる炎症を強めた.
結論:
- 食事中のイヌリン繊維は,微生物から派生したホリック酸の産生を促進する.
- これは2型炎症を引き起こします
- 発見はアレルギー性炎症,組織保護,宿主の防御に意味があります.
さらに関連する動画
09:04DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat
Published on: February 27, 2014
08:24Injections of Lipopolysaccharide into Mice to Mimic Entrance of Microbial-derived Products After Intestinal Barrier Breach
Published on: May 2, 2018
関連する概念動画
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Irritable Bowel Syndrome I: Introduction
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory Bowel Disease IV: Pharmacological Management
Pharmacologic...
Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
