関連する実験動画

Updated: Aug 23, 2025

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
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Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

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多変量線形回帰分析によるアトロポセレクティブネギシ結合最適化:KRAS G12C共性阻害剤GDC-6036の非対称合成

Jie Xu1, Samantha Grosslight2, Kyle A Mack1

  • 1Department of Small Molecule Process Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.

Journal of the American Chemical Society
|November 3, 2022
PubMed
まとめ

アトロポセレクティブ・ネギシ結合を用いて,KRAS G12C阻害体GDC-6036の効率的な合成が開発された. この方法は この重要ながん治療法への 拡張可能な経路を提供します

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Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

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