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Updated: Aug 22, 2025

Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries
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Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries

Published on: January 22, 2019

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メディエーターキナーゼモジュールをターゲットにすることで,T細胞エフェクターの活性化

Katherine A Freitas1,2, Julia A Belk3, Elena Sotillo2

  • 1Immunology Graduate Program, Stanford University School of Medicine, Stanford, CA, USA.

Science (New York, N.Y.)
|November 10, 2022
PubMed
まとめ

研究者らは,MED12とCCNCをがん免疫療法におけるT細胞機能を制限する重要な遺伝子として特定した. MED12を削除すると,抗腫瘍活性が増加し,T細胞の反応を高める新たな標的となる.

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