Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Genomics02:02

Genomics

36.9K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
36.9K
Epigenetic Regulation01:37

Epigenetic Regulation

3.1K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
3.1K
Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

6.4K
Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
6.4K
Chromatin Position Affects Gene Expression02:35

Chromatin Position Affects Gene Expression

23.5K
Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences  access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area. 
Topologically Associated Domains (TADs)
The 3-dimensional positioning of chromatin in the nucleus influences the...
23.5K
Epistasis Analysis01:09

Epistasis Analysis

5.1K
Although Mendel chose seven unrelated traits in peas to study gene segregation, most traits involve multiple gene interactions that create a spectrum of phenotypes. When the interaction of various genes or alleles at different locations influences a phenotype, this is called epistasis. Epistasis often involves one gene masking or interfering with the expression of another (antagonistic epistasis). Epistasis often occurs when different genes are part of the same biochemical pathway. The...
5.1K
Histone Modification02:32

Histone Modification

13.6K
The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
13.6K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Mitotic Cdc42 waves encode PI(3,4)P<sub>2</sub> signaling and Golgi morphological state to control spindle scaling.

Science advances·2026
Same author

Implementation of an adaptive-optics assisted isoSTED nanoscope.

Nature protocols·2026
Same author

Fluorogenic speed-optimized DNA-PAINT probes enable super-resolution imaging of whole cells.

bioRxiv : the preprint server for biology·2026
Same author

pan-ASLM: Axially Swept Light Sheet Microscopy for Fast and High-Resolution Imaging of Expanded Samples.

Npj imaging·2026
Same author

Oligomeric assembly of the gatekeeper InvE orchestrates hierarchical type III protein secretion in <i>Salmonella</i> Typhimurium.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

All-optical visualization of specific molecules in the ultrastructural context of brain tissue.

Nature biotechnology·2025
Same journal

Co-option of lysosomal machinery shapes the evolution of the intracellular photosymbiosis supporting coral reefs.

Cell·2026
Same journal

LEF1 and niche factors determine T cell stemness across chronic diseases.

Cell·2026
Same journal

Recurrent patterns of TOP1-mediated neuronal genomic damage shared by major neurodegenerative disorders.

Cell·2026
Same journal

Four-dimensional molecular mapping from a spatial snapshot reveals the dynamics of hair follicle organogenesis.

Cell·2026
Same journal

Whole-cell particle-based digital twin simulations from 4D lattice light-sheet microscopy data.

Cell·2026
Same journal

Systematic discovery of pathogen effector functions across human pathogens and pathways.

Cell·2026
関連記事をすべて見る

関連する実験動画

Updated: Aug 22, 2025

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection
09:19

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection

Published on: July 6, 2022

5.0K

オミックスは空間的エピジェノミクスになります.

Florian Schueder1, Joerg Bewersdorf2

  • 1Department of Cell Biology, Yale School of Medicine, New Haven, CT, USA; Department of Microbial Pathogenesis, Yale School of Medicine, New Haven, CT, USA.

Cell
|November 11, 2022
PubMed
まとめ
この要約は機械生成です。

空間オミクス技術は 組織内の詳細な分子データを提供します マルチプレキスされたエラー・ロバスト・フィッシュ (MERFISH) のような新しいエピジェネティック・マルチプレキス方法は,特定の組織領域における遺伝子発現の調節を研究することを可能にします.

さらに関連する動画

Author Spotlight: An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations
11:36

Author Spotlight: An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations

Published on: April 21, 2023

2.3K
An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
10:41

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

10.5K

関連する実験動画

Last Updated: Aug 22, 2025

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection
09:19

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection

Published on: July 6, 2022

5.0K
Author Spotlight: An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations
11:36

Author Spotlight: An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations

Published on: April 21, 2023

2.3K
An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
10:41

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

10.5K

科学分野:

  • 分子生物学
  • ゲノミクス
  • 細胞生物学

背景:

  • 空間オミクス技術は 組織からの高解像度分子データを提供します
  • 細胞のアイデンティティと機能を理解することは,空間的な文脈内の分子プロファイリングに依存しています.
  • エピジェノミック調節は遺伝子発現において重要な役割を果たしますが,空間的に解明された分析が必要です.

研究 の 目的:

  • 空間的な遺伝子発現分析のためのエピジェネティックマルチプレキシングアプローチを導入し,実証する.
  • 特定の組織領域における表遺伝子学的調節の研究を可能にします.
  • 細胞のプロセスを理解するための空間オミクスの能力を向上させる.

主な方法:

  • マルチプレックスされたエラーロバストFISH (MERFISH) テクニック.
  • 高通量分子プロファイリング
  • 組織で空間的に解析されたデータを取得する.

主要な成果:

  • MERFISHは,RNA分子の多重化され,エラーに耐える検出を可能にします.
  • この方法は,遺伝子発現に関する空間的に解明された情報を提供します.
  • 組織特異的な方法で表遺伝子学的調節の調査を可能にします.

結論:

  • MERFISHのようなエピジェネティック・マルチプレキシングアプローチは 空間的トランスクリプトミクスの強力なツールです
  • この技術は,定義された組織マイクロ環境内の遺伝子発現調節の研究を容易にする.
  • 複雑な生物システムの解剖には 空間オミクスの進歩が不可欠です