海馬 の 信号 は 子宮外 の 臓器 の 成長 を 指示 し ます が,正常 な 臓器 の 成長 を 指示 し ませ ん
W Kowalczyk1, L Romanelli1, M Atkins1,2
1VIB Center for Cancer Biology and KU Leuven Department of Oncology, KU Leuven, Leuven, Belgium.
まとめ
ヒッポの信号経路は 正常な臓器の成長を制御しない ヒポポテミアによる過剰成長は 異常な遺伝プログラムによるもので 正常な発達信号ではない
科学分野:
- 細胞生物学
- 発達生物学
- 遺伝学
背景:
- ヒッポシグナル伝達経路は 伝統的に臓器の大きさの 重要なレギュレータとして見られています
- ヒッポのシグナル伝達の実験的な操作は,しばしば重要な臓器過剰成長の現象につながります.
研究 の 目的:
- 臓器の正常な成長における ヒッポ信号の役割を調査する
- 細胞増殖と正常な発達と相関するかどうかを判断する.
- ヒッポが誘発した過剰成長の 遺伝的プログラムを特定するために
主な方法:
- ネズミの肝臓とドロソフィラの眼の遺伝子操作
- Yap/Taz/Ykiの転写活動と細胞増殖との相関性の分析
- ドロソフィラの機能的な遺伝子スクリーニングで,ヒッポの経路の標的遺伝子を特定します.
主要な成果:
- ヒッポの転写出力を除去すると,正常な肝臓と目の成長が妨げられませんでした.
- ヒッポ経路エフェクター活性 (Yap/Taz/Yki) は正常な細胞増殖と相関しなかった.
- 異常な遺伝子発現を誘導した 異常な遺伝子発現を誘導した 異常な遺伝子発現を誘導した
- 検査では 子宮外の過剰成長には必要ですが 正常な成長には欠かせないヒッポの標的遺伝子を特定しました
結論:
- ヒッポの信号は 正常な臓器の成長を 決定するものではありません
- ヒッポ媒介の過剰成長は 異常な遺伝プログラムから生まれます 異常な遺伝プログラムは 正常な発達を制御するプログラムから生まれます
関連する概念動画
Hedgehog Signaling Pathway
7.4K
The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
7.4K
Regulation of Angiogenesis and Blood Supply
2.7K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.7K
Notch Signaling Pathway
4.4K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
4.4K
Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal
2.3K
Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
2.3K
Endocrine Signaling
64.6K
Endocrine cells produce hormones to communicate with remote target cells found in other organs. The hormone reaches these distant areas using the circulatory system. This exposes the whole organism to the hormone but only those cells expressing hormone receptors or target cells are affected. Thus, endocrine signaling induces slow responses from its target cells but these effects also last longer.
64.6K
Role Of Notch Signalling In Intestinal Stem Cell Renewal
2.2K
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.2K


