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Updated: Aug 20, 2025

Contractions of Human-iPSC-derived Cardiomyocyte Syncytia Measured with a Ca-sensitive Fluorescent Dye in Temperature-controlled 384-well Plates
07:42

Contractions of Human-iPSC-derived Cardiomyocyte Syncytia Measured with a Ca-sensitive Fluorescent Dye in Temperature-controlled 384-well Plates

Published on: October 18, 2018

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L型Cavチャネルに対するソフォスブウィールとアミオダロンの重度の有害作用の構造的根拠

Xia Yao1, Shuai Gao1, Jixin Wang2

  • 1Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.

Cell
|November 23, 2022
PubMed
まとめ

抗ウイルス薬ソフォスブウィールと抗不律薬アミオダロンの間の致命的な薬物相互作用が調査されました. ソフォスブウィルはアミオダロンが占めるカルシウムチャネルに結合し,イオンフローを阻害し,危険な心臓リズム効果を引き起こす.

キーワード:
Ca ((v) 1.1 についてCa ((v) 1.3 についてL型Ca (v) チャンネルアミオダロンクリオ・エム薬物安全性薬物相互作用重度のブラディカルディアソフォスブウィールボルトゲートカルシウムチャネル

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Isolation of Human Atrial Myocytes for Simultaneous Measurements of Ca2+ Transients and Membrane Currents10:53

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