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Updated: Aug 20, 2025

Preparation of Synaptoneurosomes from Mouse Cortex using a Discontinuous Percoll-Sucrose Density Gradient
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Preparation of Synaptoneurosomes from Mouse Cortex using a Discontinuous Percoll-Sucrose Density Gradient

Published on: September 17, 2011

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局所タンパク質合成のシナプス型特定制御による皮質配線

Clémence Bernard1,2, David Exposito-Alonso1,2, Martijn Selten1,2

  • 1Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE1 1UL, UK.

Science (New York, N.Y.)
|November 24, 2022
PubMed
まとめ

ニューロンは局所的なタンパク質合成を用いてシナプス形成を制御する. ErbB4シグナル伝達を含む新たに特定された経路は,パルバルブミン陽性内ニューロンにおける刺激性シナプスのための特異的なメッセンジャーRNA翻訳を調節する.

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The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the...
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In eukaryotic cells, nascent mRNA transcripts need to undergo many post-transcriptional modifications to reach the cell cytoplasm and translate into functional proteins. For a long time, transcription and pre-mRNA processing were considered two independent events that occur sequentially in the cell. However, it has now been well established that transcription and pre-mRNA processing are two simultaneous processes that are precisely regulated inside the cell.
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