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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

7.8K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Tumor Immunotherapy01:27

Tumor Immunotherapy

630
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
630
Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

169
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
169
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
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Bacterial Transformation01:33

Bacterial Transformation

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In 1928, bacteriologist Frederick Griffith worked on a vaccine for pneumonia, which is caused by Streptococcus pneumoniae bacteria. Griffith studied two pneumonia strains in mice: one pathogenic and one non-pathogenic. Only the pathogenic strain killed host mice.
Griffith made an unexpected discovery when he killed the pathogenic strain and mixed its remains with the live, non-pathogenic strain. Not only did the mixture kill host mice, but it also contained living pathogenic bacteria that...
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関連する実験動画

Updated: Aug 20, 2025

Bioluminescent Bacterial Imaging In Vivo
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Bioluminescent Bacterial Imaging In Vivo

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インタラクティブながん治療法としてバクテリアを設計

Candice R Gurbatri1, Nicholas Arpaia2,3, Tal Danino1,3,4

  • 1Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA.

Science (New York, N.Y.)
|November 24, 2022
PubMed
まとめ

合成生物学を使って 設計されたバクテリアをプログラムして 腫瘍に直接がん治療を施すことができます このアプローチは,腫瘍の微小環境内の細菌の活動と治療的ペイロードの供給を制御することによって,治療の安全性と有効性を高めます.

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Bacterial Delivery of RNAi Effectors: Transkingdom RNAi
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関連する実験動画

Last Updated: Aug 20, 2025

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Published on: November 4, 2012

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Measuring Growth and Gene Expression Dynamics of Tumor-Targeted S. Typhimurium Bacteria
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科学分野:

  • 合成生物学
  • 微生物療法
  • 癌の研究

背景:

  • 微生物は腫瘍の植民者として 認識されるようになりました
  • バクテリアは腫瘍特有の 配送システムとして設計できます
  • エンジニアリングされたバクテリアは,固有の免疫性と局所的なペイロード生産を通じて腫瘍の微環境を調節することができます.

研究 の 目的:

  • 治療用バクテリアの空間的・時間的な制御を 強化するために 遺伝的回路を 検討する.
  • バクテリア,腫瘍細胞,免疫細胞の相互作用の工学を記述する.
  • バクテリアを他の治療法と組み合わせる過程を探る

主な方法:

  • 治療用バクテリアの制御のための遺伝回路のレビュー.
  • バクテリア-腫瘍細胞-免疫細胞の相互作用を工夫する
  • 細菌療法のための組み合わせ戦略の開発

主要な成果:

  • 遺伝子回路は 治療用の細菌の 空間的・時間的な制御を 強化します
  • エンジニアリングの相互作用は 細菌治療の安全性と有効性を向上させます
  • 細菌剤と他の方法の組み合わせは有望です

結論:

  • 合成生物学では プログラム可能な細菌ベースの薬の開発が可能です
  • 細菌によるがん治療の進歩には 技術的な相互作用が鍵となります
  • この分野は 合成生物学による プログラム可能な薬の概念に向かっています