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Updated: Aug 19, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
05:33

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines

Published on: November 9, 2020

10.0K

ブリッジド・プロテオリシス・ターゲティング・キメラ (PROTAC) は,薬剤耐性の標的の劣化を可能にします

Yan Xiong1, Yue Zhong1, Hyerin Yim1

  • 1Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences, Oncological Sciences and Neuroscience, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States.

Journal of the American Chemical Society
|November 30, 2022
PubMed
まとめ

新しいブリッジドプロテオリシス・ターゲティング・キメラ (PROTAC) 戦略により,以前は薬剤で処理できなかったタンパク質の分解が可能になる. このアプローチは,小分子結合物質が欠けているタンパク質であるサイクリンD1を分解し,新しい治療法を提供することに成功した.

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Author Spotlight: Evaluating Biophysical Assays for Characterizing PROTACS Ternary Complexes07:22

Author Spotlight: Evaluating Biophysical Assays for Characterizing PROTACS Ternary Complexes

Published on: January 12, 2024

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Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs10:44

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs

Published on: May 15, 2019

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