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Updated: Aug 19, 2025

Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation
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μ-オピオイド受容体のためのビトピーリガンドの構造ベースの設計

Abdelfattah Faouzi1, Haoqing Wang2, Saheem A Zaidi3

  • 1Center for Clinical Pharmacology, University of Health Sciences and Pharmacy and Washington University School of Medicine, St Louis, MO, USA.

Nature
|November 30, 2022
PubMed
まとめ

研究者は,より安全な鎮痛剤を作るため,ミューオイド受容体 (μOR) のナトリウムイオン部位を標的とした新しいフェンタニル誘導体を設計した. これらの化合物は副作用の減少を示し 鎮痛剤の開発に有望な新しい道を示しています

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