社会的トラウマは 横隔膜回路を動かし 社会的報酬を遮断する
Long Li1,2, Romain Durand-de Cuttoli1,2, Antonio V Aubry1,2
1Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Nature
|November 30, 2022
まとめ
社会的トラウマは 社会的報酬の処理を妨害し 避けることにつながります ネズミでは,ストレスの誘発による側隔膜ニューロテンシン (NTLS) ニューロンの過活性は,報酬の知覚を変化させることで,この社会的回避を促します.
科学分野:
- 神経科学
- 行動科学
- 精神科
背景:
- 社会的トラウマは 精神疾患と関連しています
- 社会的なトラウマは 脳の報酬機能を損なわせ 社会的な逃避を引き起こします
- 慢性的な社会的敗北ストレス (CSDS) モデルは,ネズミのストレス感受性と回復力を調査します.
研究 の 目的:
- マウスの社会報酬に対するCSDSの影響を調査する.
- 社会的トラウマの後に 社会的回避の基礎となる 神経的メカニズムを特定する
主な方法:
- マスとメスのマウスにおける慢性的な社会的敗北ストレス (CSDS) モデル.
- 社会的相互作用と報酬を測定するための行動分析
- 全脳フォースマッピング, インビオCa2+画像, 全細胞記録.
- オプトジェネティックとケミオジェネティックによる特定のニューロン集団の操作
主要な成果:
- マウスのサブセット (感受性SUS) は,CSDS後に社会的回避と社会的報酬の欠如を示した.
- 非社会的ストレス要因は 社会的報酬に影響しませんでした
- ストレス/脅威に反応する横隔膜ニューロテンシン (NTLS) ニューロンは,特にSUSマウスにおける社会的相互作用によって活性化されました.
- NTLSニューロンの操作により 社会的相互作用と報酬が調節されます
結論:
- CSDSは社会的回避を誘発し,社会的報酬の処理に障害がある.
- SUSマウスの過度に活発なNTLSニューロンは,社会的標的を脅威として認識し,社会的報酬を遮断します.
- NTLSニューロンは ストレスに起因する社会的欠陥に対する 潜在的な治療目標です
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