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Updated: Aug 19, 2025

Visualizing and Quantifying Endonuclease-Based Site-Specific DNA Damage
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アクティブ DNA 脱メチル化は,細胞の運命の仕様とDNA 損傷反応を促進する

Dongpeng Wang1, Wei Wu1,2, Elsa Callen1

  • 1Laboratory of Genome Integrity, National Cancer Institute NIH, Bethesda, MD, USA.

Science (New York, N.Y.)
|December 1, 2022
PubMed
まとめ

メチルサイトシンに対する 10−11 転位 (TET) 酵素の活動は,神経細胞の DNA 断裂を引き起こします. 細胞のアイデンティティに不可欠なこのプロセスは 特定のがん薬で神経毒性を引き起こします

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