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Updated: Aug 18, 2025

Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries
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Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries

Published on: January 22, 2019

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結合信号モチーフライブラリと機械学習を使用してCAR T細胞フェノタイプを解読する

Kyle G Daniels1,2, Shangying Wang3,4, Milos S Simic1,2

  • 1Cell Design Institute, University of California, San Francisco, San Francisco, CA 94158, USA.

Science (New York, N.Y.)
|December 8, 2022
PubMed
まとめ

研究者は合成信号モチーフを使用して新しいキメリック抗原受容体 (CAR) を設計した. マシン・ラーニングは 設計ルールを特定し T細胞の機能を向上させ 免疫療法で腫瘍を殺します

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T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
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Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
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