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関連する概念動画

Eukaryotic Compartmentalizations01:46

Eukaryotic Compartmentalizations

137.2K
One of the distinguishing features of eukaryotic cells is that they contain membrane-bound organelles, such as the nucleus and mitochondria, that carry out specialized functions. Since biological membranes are only selectively permeable to solutes, they help create a compartment with controlled conditions inside an organelle. These microenvironments are tailored to the organelle's specific functions and help isolate them from the surrounding cytosol.
For example, lysosomes in the animal cells...
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Contact-dependent Signaling01:19

Contact-dependent Signaling

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Contact-dependent signaling, as the name suggests, requires that communicating cells be in direct contact with each other. This is achieved either through receptor-ligand interactions or by specialized cytoplasmic channels that allow the flow of small molecules between cells. In animal cells, channels called gap junctions facilitate contact-dependent signaling in certain tissues, whereas, plasmodesmata perform a similar function in plants.
Gap Junctions
In animal cells, gap junctions are formed...
40.2K
What are Membranes?01:54

What are Membranes?

156.6K
A key characteristic of life is the ability to separate the external environment from the internal space. To do this, cells have evolved semi-permeable membranes that regulate the passage of biological molecules. Additionally, the cell membrane defines a cell’s shape and interactions with the external environment. Eukaryotic cell membranes also serve to compartmentalize the internal space into organelles, including the endomembrane structures of the nucleus, endoplasmic reticulum and...
156.6K
What are Membranes?01:24

What are Membranes?

14.5K
A cell's plasma membrane demarcates the cell's borders and determines the nature of its interaction with the environment. Cells exclude certain substances, take in others, and excrete some others in controlled quantities. The plasma membrane must be flexible to allow certain cells, such as red and white blood cells, to change their shape while passing through narrow capillaries. These are the more obvious plasma membrane functions. In addition, the plasma membrane's surface carries...
14.5K
The Phragmoplast01:59

The Phragmoplast

5.0K
Cell division is essential for organismal growth and development. In animal cells, the central spindle and its associated proteins form the midbody, a structure that has an essential role in cytokinesis. In plants, the central spindle, along with the microtubules, actin, and other cell components, matures into the phragmoplast, which is necessary for cytokinesis. Unlike the stationary midbody, the phragmoplast expands centrifugally, eventually leading to the formation of the new cell wall.
The...
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Eukaryotic Compartmentalization01:37

Eukaryotic Compartmentalization

13.9K
One of the distinguishing features of eukaryotic cells is that they contain membrane-bound organelles, such as the nucleus and mitochondria, that carry out specialized functions. Since biological membranes are only selectively permeable to solutes, they help create a compartment with controlled conditions inside an organelle. These microenvironments are tailored to the organelle's specific functions and help isolate them from the surrounding cytosol.
For example, lysosomes in the animal...
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関連する実験動画

Updated: May 2, 2026

Bimolecular Fluorescence Complementation
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Bimolecular Fluorescence Complementation

Published on: April 15, 2011

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細胞に二機能分子を入れる

R Scott Lokey1, Cameron Pye2

  • 1Department of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, CA, USA.

Science (New York, N.Y.)
|December 8, 2022
PubMed
まとめ
この要約は機械生成です。

トランスメブランタンパク質は 細胞膜を横切って 大量の薬物を運ぶための鍵です この発見は 薬物投与システムに 新たな道を開きます

さらに関連する動画

High Yield Expression of Recombinant Human Proteins with the Transient Transfection of HEK293 Cells in Suspension
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Bead Loading Proteins and Nucleic Acids into Adherent Human Cells
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Bead Loading Proteins and Nucleic Acids into Adherent Human Cells

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Bimolecular Fluorescence Complementation
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Bimolecular Fluorescence Complementation

Published on: April 15, 2011

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High Yield Expression of Recombinant Human Proteins with the Transient Transfection of HEK293 Cells in Suspension
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科学分野:

  • 生物化学
  • 細胞生物学
  • 薬理学について

背景:

  • 細胞膜は 薬の投与に重大な障壁となっています
  • トランスメブランタンパク質は 細胞輸送において重要な役割を果たします
  • 効率的な薬の投与には 細胞膜の障壁を乗り越える必要があります

研究 の 目的:

  • 大量の薬物分子の輸送に関与するトランスメブランタンパク質を特定し,特徴づけること.
  • 新薬の配達手段として これらのタンパク質の可能性を 探求する

主な方法:

  • プロテオミク解析を用いて,トランスメブランタンパク質候補を特定した.
  • 薬物輸送能力を検証するために細胞ベースの測定法を使用した.
  • 分子モデリングを通じてタンパク質の構造と機能を調査した.

主要な成果:

  • 大量の薬物の通過を容易にする特定の細胞膜タンパク質が特定されました.
  • これらのタンパク質が 薬物のペイロードを結合し 転位する能力を示した.
  • これらのタンパク質によって媒介される輸送のメカニズムを特徴づけた.

結論:

  • トランスメブランタンパク質は 大量の薬物の投与を 促進する有望な手段です
  • これらのタンパク質トランスポーターを ターゲットにすることで 薬物開発と治療戦略に 革命が起こります