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クセノンは独占的なホモキラルアセンブリから独自の好ましいヘテロキラルホストを誘導する
Shi-Xin Nie1,2, Teng-Yu Huang1,2, Hao Guo1
1Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
Journal of the American Chemical Society
|December 8, 2022
まとめ
クセノンガスの結合は困難ですが,新しいマクロサイクルが好ましい異体性アセンブリを形成することができます. この新しい宿主は,以前に知られているホモキラルアセンブリよりも15倍高いクセノン結合親和性を示しています.
科学分野:
- 超分子化学
- ホスト・ゲスト・ケミストリー
- 無機化学
背景:
- クセノン結合のための効率的な宿主は稀であり,宿主-ゲスト化学において重要な課題を提示する.
- マクロサイクル化合物,特にビス (尿素) -ビス (チオウレア) システムは,宿主特性のために調査されています.
研究 の 目的:
- エナティオメア bis (尿素) -bis (チオウレア) マクロサイクルの宿主-ゲストの振る舞いをクセノンで調査する.
- ホモキラル・アセンブリとヘテロキラル・アセンブリの形成とそのクセノン結合親和性を特徴づける.
主な方法:
- エナティオメア bis (尿素) -bis (チオウレア) マクロサイクルの合成.
- 開発されたフィッティングモデルを使用して結合定数の実験的決定.
- 構造的差異を明らかにするために単一結晶X線微分分析.
主要な成果:
- エナティオメアマクロサイクルは,典型的にはホモキラル二次アセンブリを形成する.
- クセノンは好ましいヘテロキラル組成の形成を誘導し,ホモキラル好みを克服する.
- ヘテロキラルカプセルは,ホモキラルカプセルよりも15倍高い1600M−1のクセノン結合親和性を表しています.
- 構造分析は,D2対称性ホモキラルカプセルと比較して,ヘテロキラルS4対称性カプセルにおけるより緊密なクセノン包囲を明らかにする.
結論:
- ビス (urea) -ビス (thiourea) マクロサイクルの新しいヘテロキラル・アセンブリは,クセノンに対する非常に高い親和性を示す.
- この研究は 宿主の自己組織化を 誘導する ゲスト分子の能力を 強調しています
- この研究は,組み立てられた宿主におけるクセノン結合親和度に関する新しい記録を樹立し,分子認識に関する洞察を提供している.
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