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Updated: Aug 18, 2025

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
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Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine

Published on: June 13, 2022

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軽度のC-Hカルボキシル化による多様なアゾールカルボキシル酸の構成要素へのアクセス:並列の1ポットアミド結合と機械学習による基板の範囲設計

Stephanie Felten1, Cyndi Qixin He2, Mark Weisel1

  • 1Process Research & Development, MRL, Merck & Co. Inc, 126 E Lincoln Avenue, Rahway, New Jersey 07065, United States.

Journal of the American Chemical Society
|December 9, 2022
PubMed
まとめ

新しい無金属C-H炭酸化法により,アゾール2炭酸およびアミドに直接アクセスできます. この効率的なプロトコルは,シリルトリフラート反応剤を用いてアゾール-2-アミドの化学空間を拡大します.

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Direct alkylation of ammonia produces polyalkylated amines, along with a quaternary ammonium salt. To exclusively prepare primary amines, the azide synthesis method can be used.
Azide ions act as good nucleophiles and react with unhindered alkyl halides to form alkyl azides. Alkyl azides do not participate in further nucleophilic substitution reactions, thereby eliminating the chances of polyalkylated products. Alkyl azides are reduced by hydride-based reducing agents, like lithium aluminum...
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