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Updated: Aug 17, 2025

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ATG9Aは,非伝統的なリソソーム標的経路によってTNF細胞毒性を防止する

Jon Huyghe1,2, Dario Priem1,2, Lisette Van Hove1,2

  • 1VIB Center for Inflammation Research, 9052 Ghent, Belgium.

Science (New York, N.Y.)
|December 15, 2022
PubMed
まとめ

腫瘍死滅因子 (TNF) は細胞死を引き起こすが,ATG9AとFIP200を含む新しいチェックポイントは,細胞毒性複合体を分解することによってこれを防ぐ. このメカニズムは,TNF受容体1 (TNFR1) 媒介の胚死亡と皮膚炎から保護します.

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