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関連する概念動画

Maturation of Endosomes01:28

Maturation of Endosomes

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The early endosome containing internalized molecules matures through transformations in its location, morphology, intraluminal pH, and membrane protein composition. Together, these changes result in a more acidic late endosome that contains multiple intraluminal vesicles; therefore, the late endosome is also called a multivesicular body (MVB).
Changes in location
The maturing endosome moves along microtubules from the periphery of the cell towards the perinuclear region. This movement of the...
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Recycling Endosomes and Transcytosis00:58

Recycling Endosomes and Transcytosis

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The recycling endosome, also known as the endosomal recycling compartment (ERC), is a part of the slow-recycling process of the endocytic pathway. Molecules internalized through receptor-mediated endocytosis are either degraded in the lysosomes or are recycled to the plasma membrane through the fast- or slow-recycling route.
The recycling endosome is not a single organelle but an extensively tubulated network of recycling pathways. It functions in storing molecules or transporting them across...
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The Early Endosome: Endocytosis of Transferrin01:28

The Early Endosome: Endocytosis of Transferrin

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Essential proteins such as insulin or low-density lipoprotein (LDL) and micronutrients such as iron enter a eukaryotic cell through receptor-mediated endocytosis. Subsequently, the early endosomes fuse with the vesicles containing such receptor-ligand complexes and play a vital role in sorting the incoming ligands and receptors. While the ligands are either degraded inside the vesicle or released into the cytosol, their receptors are returned to the plasma membrane for further rounds of...
3.4K
Intralumenal Vesicles and Multivesicular Bodies01:38

Intralumenal Vesicles and Multivesicular Bodies

3.6K
Intraluminal vesicles (ILVs) are small vesicles 50-80 nm in diameter formed during the maturation of early endosomes. A specialized endosome containing numerous ILVs is called a multivesicular body (MVB). ILVs contain internalized molecules such as antigens, nucleic acids, proteins, and metabolites. Some of these molecules are released from the MVBs inside exosomes and are transported to other cells. Other MVBs contain molecules that are retained in the ILVs and are later degraded within the...
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Lysosomes01:31

Lysosomes

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Lysosomes are membrane-enclosed spherical sacs derived from the Golgi apparatus. The most important function of the lysosome is degrading macromolecules and biological polymers that are released during membrane trafficking events such as the secretory, endocytic, autophagic, and phagocytic pathways. The degradation is carried out by several hydrolytic enzymes active in an acidic environment of the lysosomal lumen. These acid hydrolases are involved in cellular processes such as cell signaling,...
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Export of Misfolded Proteins out of the ER01:32

Export of Misfolded Proteins out of the ER

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After folding, the ER assesses the quality of secretory and membrane proteins. The correctly folded proteins are cleared by the calnexin cycle for transport to their final destination, while misfolded proteins are held back in the ER lumen. The ER chaperones attempt to unfold and refold the misfolded proteins but sometimes fail to achieve the correct native conformation. Such terminally misfolded proteins are then exported to the cytosol by ER-associated degradation or ERAD pathway for...
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関連する実験動画

Updated: Aug 17, 2025

Site-specific Bacterial Chromosome Engineering: ΦC31 Integrase Mediated Cassette Exchange (IMCE)
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Site-specific Bacterial Chromosome Engineering: ΦC31 Integrase Mediated Cassette Exchange (IMCE)

Published on: March 16, 2012

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エンジニアとしてのエンドソーム

Maria Clara Zanellati1, Sarah Cohen1

  • 1Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Science (New York, N.Y.)
|December 15, 2022
PubMed
まとめ
この要約は機械生成です。

エンドソームは 複雑な脂質シグナル伝達経路を通じて 栄養素の利用可能性に基づいて 動的に形を変えます このプロセスは細胞の栄養分感と 臓器の適応に不可欠です

さらに関連する動画

Author Spotlight: Development of a Large-Scale, Reproducible Production Method for Exosome Mimetics Using Magnetic Nanoparticles
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Engineering Cell-permeable Protein
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Engineering Cell-permeable Protein

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関連する実験動画

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Site-specific Bacterial Chromosome Engineering: ΦC31 Integrase Mediated Cassette Exchange (IMCE)
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Author Spotlight: Development of a Large-Scale, Reproducible Production Method for Exosome Mimetics Using Magnetic Nanoparticles
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Engineering Cell-permeable Protein
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Engineering Cell-permeable Protein

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科学分野:

  • 細胞生物学
  • 分子生物学
  • 生物化学

背景:

  • エンドソームは細胞内取引と分類に関与する 重要な臓器細胞です
  • 臓器細胞の形態は細胞の機能と適応に不可欠である.
  • 脂質シグナル伝達は 細胞のプロセスを調節する上で 重要な役割を果たします

研究 の 目的:

  • エンドソームの形状調節における脂質シグナル伝達の役割を調査する.
  • エンドソームの形状に 栄養素のレベルがどう影響するかを理解する
  • 栄養素感知とオルガネルのダイナミクスを結びつける分子メカニズムを解明する.

主な方法:

  • エンドソームの動態を視覚化するために 先進的な顕微鏡技術を使用しました
  • 主要なシグナリング脂質を特定するために,脂質解析を用いた.
  • 特定の脂質調節酵素の機能を調べるために 遺伝子操作を行いました

主要な成果:

  • 特定の脂質がエンドソーム膜の曲線と形に直接影響することを示した.
  • 細胞の栄養状態とレギュレータ性脂質の量との間には直接的な相関関係があることが示された.
  • 栄養依存性エンドソーム再構成に不可欠な新しい脂質調節酵素を特定した.

結論:

  • 脂質シグナル伝達は,エンドソームが栄養素の可用性に応じて形状を調整する主要なメカニズムです.
  • この適応プロセスは,異なる栄養条件下で細胞の恒常性を維持するために重要です.
  • この発見は,臓器細胞のダイナミックな性質と,細胞環境への反応に関する新しい洞察を提供します.