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Updated: Aug 16, 2025

Defining Hsp33's Redox-regulated Chaperone Activity and Mapping Conformational Changes on Hsp33 Using Hydrogen-deuterium Exchange Mass Spectrometry
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Defining Hsp33's Redox-regulated Chaperone Activity and Mapping Conformational Changes on Hsp33 Using Hydrogen-deuterium Exchange Mass Spectrometry

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ヘテロディスルファイド還元酵素HdrBにおけるノンキュバンの [4Fe-4S] クラスタの基質依存型コンフォームスイッチ

Vladimir Pelmenschikov1, Delfim Ferreira2, Sofia S Venceslau2

  • 1Institut für Chemie, Technische Universität Berlin, 10623 Berlin, Germany.

Journal of the American Chemical Society
|December 21, 2022
PubMed
まとめ

ヘテロディスルファイド還元酵素 (HdrB) には,ユニークなノンキューバン [4Fe-4S] クラスターが含まれています. サブストラット結合は,システインリガンドスイッチを含む,閉じた状態から開いた状態への構成変化を引き起こす.

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