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Updated: Aug 16, 2025

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腫瘍におけるキメラ前薬活性化を標的とした放射線治療によるタンパク質分解

Chunrong Yang1, Yuchen Yang1, Yujie Li2

  • 1Department of Chemistry, Center for Bioanalytical Chemistry, Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Tsinghua University, Beijing 100084, China.

Journal of the American Chemical Society
|December 21, 2022
PubMed
まとめ

放射線療法によるPROTAC前薬 (RT-PROTACs) は,タンパク質の分解を正確に制御し,全身の毒性を最小限に抑えることができます. この新しいアプローチは,標的治療のためにX線放射線を用いてPROTACsを活性化します.

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