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Updated: Aug 16, 2025

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R-ループ派生の細胞質RNA-DNAハイブリッドは免疫反応を活性化させる

Magdalena P Crossley1, Chenlin Song1, Michael J Bocek1

  • 1Department of Chemical and Systems Biology, Stanford University, Stanford, CA, USA.

Nature
|December 21, 2022
PubMed
まとめ

R-ループはRNA-DNAのハイブリッドで 誤って処理され 細胞質に蓄積すると 生まれつきの免疫反応を誘発します この異常な蓄積は 細胞死を招き 癌や神経変性などの 病気を引き起こす可能性があります

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