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Updated: Aug 16, 2025

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death
09:18

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death

Published on: December 27, 2016

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アポトーシス-シグナル調節キナーゼ1を加速するタンパク質フォスファタゼ5-リクルートキメラ

Qiuyue Zhang1,2, Xuexuan Wu1,2, Hengheng Zhang1,2

  • 1State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China.

Journal of the American Chemical Society
|December 22, 2022
PubMed
まとめ

研究者らは,PP5をp-ASK1 ((T838) を脱酸化させる新しいキメラであるDDO3711を開発し,胃がんの進行を効果的に減少させました. この標的型アプローチは,異常にリン酸化されたオンコタンパク質の調節に有望である.

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