ゼブラフィッシュの自己位置記憶と位置性ホメオスタシスのための脳幹統合器

En Yang¹, Maarten F Zwart², Ben James¹

¹Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA.

Cell

|December 23, 2022

まとめ

幼虫のゼブラフィッシュは位置を追跡し補正泳いで戻ることができますこの行動は自己運動を統合し位置記憶を保存する後頭脳の回路によって制御されます

科学分野:

神経科学
比較生物学
動物の行動

背景:

哺乳類のヒポカンプスで知られている位置表現で動きを統合することで動物は自己位置を追跡します
古代の脳領域が自己定位を表しているか移動を制御するために自己運動が一体化しているかは不明です

研究の目的:

古代の脳領域の位置表現を調査する
ポジショナルの記憶を統合した自己運動が作り出す方法を理解する
移動を制御する神経経路を特定する

主な方法:

仮想現実で頭が固定された想像上の泳ぐゼブラフィッシュの幼虫モデルを使いました
ゼブラフィッシュを非自発的な空間移動に晒しその反応をモニターしました
全脳機能イメージング,光遺伝学,および病変の研究を使用しました.

主要な成果:

ゼブラフィッシュは不意の移動を追跡し元の場所に戻るための補正泳ぎを開始し "ポジショナルのホメオスタシス"を示しました
位置記憶とエラーシグナルを生成する上で重要であることが判明しました
骨髄統合細胞の光遺伝的刺激により移位記憶の行動が誘発され切除により補正泳ぎが廃止された.

結論:

脊椎動物における多領域の後脳回路は,自己運動を統合し,自己位置を保存して運動行動を制御する.
この回路は古代の脊椎動物の脳における空間的なナビゲーションとオリエンテーションの基本的メカニズムです
この発見は,脊椎動物の自己位置追跡と修正行動のための保存された神経基盤を明らかにしています

キーワード:

脳幹について小脳ヒポカンプス劣ったオリーブメモリモーターコントロールナビゲーション神経回路神経科学パスインテグレーションゼブラフィッシュ

さらに関連する動画

09:16

Stab Wound Injury of the Zebrafish Adult Telencephalon: A Method to Investigate Vertebrate Brain Neurogenesis and Regeneration

Published on: August 4, 2014

15.5K

08:35

Shuttle Box Assay as an Associative Learning Tool for Cognitive Assessment in Learning and Memory Studies using Adult Zebrafish

Published on: July 12, 2021

4.6K

関連する概念動画

01:11

Cerebrum: Anatomical Overview II

4.9K

Each cerebral hemisphere can be divided into three main regions. The outermost region, the cerebral cortex, is a thin layer (2 to 4 millimeters thick) made up of gray matter, consisting of neuron cell bodies, dendrites, glial cells, and blood vessels. The middle region, or white matter, is primarily composed of myelinated nerve fibers organized into three types of large tracts: association fibers, commissures, and projection fibers. Association fibers connect different areas within the same...

4.9K

01:30

Diencephalon: Anatomical Regions

6.0K

The diencephalon, etymologically translated as 'through brain,' plays an integral role as the conduit between the cerebrum and the vast extent of the nervous system. However, the olfactory system is an exception, as it interfaces directly with the cerebrum. The diencephalon, deeply ensconced beneath the cerebrum, primarily consists of three paired structures — the thalamus, hypothalamus, and epithelamus. It also includes accessory structures such as the subthalamus, which houses the...

6.0K

01:19

Brainstem

7.5K

The brainstem, located inferior to the brain and superior to the spinal cord, serves as a bridge between the cerebrum and the spinal cord. It plays a vital role in relaying information and controlling critical life functions. It comprises three primary regions: the midbrain, pons, and medulla oblongata.
The Midbrain
The midbrain is located beneath the diencephalon and connects the cerebrum with the lower parts of the brain. The cerebral peduncles are prominent midbrain structures that house the...

7.5K

01:21

Cerebrospinal Fluid

7.9K

Cerebrospinal fluid (CSF) is a colorless liquid that flows around the brain and the spinal cord, playing a vital role in the protection, support, and overall function of the central nervous system (CNS). CSF production, circulation, and absorption are tightly regulated processes essential for the brain and spinal cord to function properly.
CSF Production
CSF is produced mainly in the choroid plexus, a network of capillaries and ependymal cells located within the ventricular system of the brain....

7.9K

01:19

Role of Hippocampus in Memory

2.0K

The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...

2.0K

01:14

Role of Cerebellum and Prefrontal Cortex in Memory

1.5K

The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...