COVID-19後のmRNAワクチンの心筋炎で検出された循環スパイクタンパク質

Lael M Yonker^1,2,3, Zoe Swank^3,4, Yannic C Bartsch^3,5

¹Mucosal Immunology and Biology Research Center (L.M.Y., M.D.B., A.K., B.P.B., J.P.D., M.L., A.F.), Division of Infectious Disease, Massachusetts General Hospital, Boston.

Circulation

|January 4, 2023

まとめ

若者におけるmRNAワクチン接種後の心筋炎は,同様の免疫反応を示したが,感染した個体ではフリースパイクタンパク質のレベルが高かった. この発見は,ワクチン接種後の心筋炎の潜在的な原因に関する新しい洞察をもたらします.

科学分野:

免疫学
ワクチン学
心臓病科

背景:

mRNA重症急性呼吸器症候群コロナウイルス2型 (SARS-CoV-2型) ワクチン接種後の青少年および若年において報告された心筋炎の症例.
これらの個体に対する詳細な免疫プロファイルは限られている.

研究の目的:

SARS-CoV-2 mRNAワクチン接種後に心筋梗塞を発症した青少年および若い成人の免疫プロフィールを調査する.
ワクチン接種後の心筋炎患者と健康なワクチン接種した対照群の免疫反応を比較する.

主な方法:

ワクチン接種後の心筋炎を患った16人の入院患者からの採血.
広範な抗体プロファイリング,T細胞分析,サイトカイン,抗原プロファイリング.
年齢相応の45人の健康なワクチン対照群との比較

主要な成果:

免疫反応 (抗体とT細胞) は,筋炎患者と対照群に類似した.
心筋炎の症例では,サイトカインの産生がわずかに増加した.
筋肉炎の患者では,SARS-CoV-2のフリースパイクタンパク質のレベルが著しく上昇したが,対照群ではそうではなかった.

結論:

mRNAワクチンによる免疫反応は,心筋炎を発症した人と発症しなかった人の間で異なることはありません.
血液中のフリー・スパイク・アンチゲンの存在は,mRNAワクチンの後の心筋炎の根本的な原因の洞察を与える可能性があります.

キーワード:

コロナウイルス SARS-CoV-2について mRNA について心筋炎ワクチン

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