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Updated: Aug 15, 2025

Characterizing RNA Modifications in Single Neurons Using Mass Spectrometry
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Characterizing RNA Modifications in Single Neurons Using Mass Spectrometry

Published on: April 21, 2022

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METTL1-WDR4による調節されたm7G tRNAの構造的基礎

Jiazhi Li1,2,3, Longfei Wang2,4,5, Quentin Hahn1

  • 1Stem Cell Program, Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA.

Nature
|January 4, 2023
PubMed
まとめ

METTL1- WDR4複合体は,細胞機能に不可欠な転送RNA (tRNA) を修正する. この研究では,WDR4がMETTL1とtRNAを組み立て,N末端のリン酸化がメチルトランスファーゼの活性を調節する方法を明らかにした.

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