病原菌はフェロモン反応を調節し,交尾を促進する
Taihong Wu1,2, Minghai Ge1,2, Min Wu1,2
1Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, USA.
Nature
|January 4, 2023
まとめ
病原体は動物の社会行動を変えることができます C.エレガンスの虫では 細菌の病原体がペロモンを感知し 繁殖と適応を促すことで 交配の行動を変化させます
科学分野:
- 神経科学
- 行動エコロジー
- 微生物学
背景:
- ホストと病原体の相互作用は,動物の社会的行動に大きな影響を与えます.
- 病原体による社会行動の変化を誘発する神経メカニズムは ほとんど未知のままです
研究 の 目的:
- 病原体による社会的行動の可塑性の ニューロンの基礎を調査する
- バクテリアの病原体が 社会的相互作用と交配行動を 制御する仕組みを理解するためです
主な方法:
- 成人C.elegansのヘルマフロディトのPseudomonas aeruginosaへの暴露
- AWA感覚ニューロンの化学受容体STR-44発現の分析
- 病原体曝露後のフェロモン反応と交尾行動の評価
主要な成果:
- AWAニューロンのSTR-44発現を誘発し,フェロモン回避を変化させた.
- AWAニューロンのSTR-44は,フェロモン反応の病原体誘発の変化に不可欠です.
- C. elegans hermaphroditesは,STR-44に依存して,病原体曝露後にオスとの交配率が増加した.
結論:
- 社会的行動における病原体誘発の可塑性は,C. elegansの化学受容体STR-44によって媒介される.
- このメカニズムは 交配率を高めることで 遺伝的多様性と宿主適応を促進します
- この研究では 病原体の存在と 特定の神経経路による 社会的行動の変化との間には 直接的な関連性があることが明らかになりました
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