細胞と細胞の代謝物質の交換は 生存を促進する代謝環境を作り, 寿命を延長します
Clara Correia-Melo1, Stephan Kamrad2, Roland Tengölics3
1The Molecular Biology of Metabolism Laboratory, The Francis Crick Institute, London NW1 1AT, UK; Department of Biochemistry, University of Cambridge, Cambridge CB2 1QW, UK; Department of Biochemistry, Charité - Universitätsmedizin Berlin, 10117 Berlin, Germany.
Cell
|January 7, 2023
まとめ
酵母細胞間の代謝は老化に影響します 若い細胞は 輸出された代謝物質を老化する細胞で再輸入し 世代間の代謝協力によって 寿命が延びるのです
科学分野:
- 細胞・分子生物学
- 老化に関する研究
- 代謝相互作用
背景:
- 代謝は老化プロセスと密接に関連しています
- 以前の研究は細胞内代謝,成長制御,信号伝達経路に焦点を当てていた.
- 細胞間代謝物質の交換が老化に与える役割は,まだ十分に研究されていない.
研究 の 目的:
- メタボリート交換が酵母菌の年代的老化に及ぼす影響を調査する.
- 代謝的に協力するコミュニティの 寿命延長の可能性を探る
主な方法:
- イーストの年代測定モデルを使用した.
- メタボリート交換を促進する自己組織化メタボリート協力コミュニティ (SeMeCo)
- 特定の細胞集団における代謝再構成と代謝産物輸出を分析した.
主要な成果:
- 若い細胞のエクスポートされた代謝物質が老化細胞によって再輸入される世代間代謝相互作用が特定された.
- メタボリート交換が増加したSeMeCoで寿命が大幅に延長されたことが実証されました.
- メチオニン消費細胞の代謝変化が観察され,保護性代謝産物の輸出が増加した.
結論:
- メタボライト交換の相互作用は,細胞の老化を決定する重要な要因です.
- 代謝で協力する細胞は 環境を変化させ 長寿を促すことができます
- 細胞間代謝通信をターゲットにすることで 老化への介入の新たな戦略が生まれます
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