老化中の内生レトロウイルスの復活は老化を強化する
Xiaoqian Liu1, Zunpeng Liu2, Zeming Wu3
1State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; Institute for Stem cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Cell
|January 7, 2023
まとめ
エンドゲノス・レトロウイルス (ERV) と呼ばれる古代のウイルスは 老化中に目覚め 細胞の衰えと組織の退化を引き起こします これらのERVを抑制することで 老化マーカーを緩和します
科学分野:
- ゲノミクス
- 老化に関する研究
- ウイルス学
背景:
- 内生レトロウイルス (ERV) は,ゲノム内の不活性なウイルス要素です.
- 老化過程におけるERVの役割はほとんど未知のままです.
- ヒト内生レトロウイルスK (HERVK/HML-2) のような最近のERVは,最近統合されたため,特に興味深い.
研究 の 目的:
- 細胞の老化と生物の老化における目覚めたERVの潜在的な役割を調査する.
- HERVKの活性化がフェノタイプの老化に寄与するかどうかを判断する.
- 老化におけるERV活性化をターゲットとする治療戦略を探求する.
主な方法:
- 人間の老化細胞における遺伝子発現の分析
- HERVKによって生成されたレトロウイルス型の粒子 (RVLP) の検出と特徴付け.
- HERVKのRVLPを中和抗体で実験的に阻害する.
- 老いた動物モデル (霊長類,マウス) とヒトの組織におけるERV活性化の試験
- 衰老と老化のマーカーに対するERV抑制の効果の評価
主要な成果:
- 人間の老化細胞は,HERVKのトランスクリプションとHERVKRVPsの生産が解き放たれている.
- HERVK RVLPは老化現象型を若い細胞に伝達することができる.
- 中和抗体はHERVK RVLPの効果を阻害する.
- ERVの活性化は老いた霊長類やマウスの臓器,老人の組織や血清で観察されています.
- ERVの抑制は細胞衰老,組織変性,生物の老化を減少させます.
結論:
- 内生レトロウイルスの再活性化,特にHERVKは,細胞衰老と生物の老化の重要な特徴です.
- 覚醒したERVは 老化過程の原動力として作用します
- ERV再活性化をターゲットにすることで,年齢関連の衰えを緩和する潜在的な治療方法が提示されます.
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