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Updated: Aug 14, 2025

Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens
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γδ T細胞は,HLAクラスI欠陥を有するがんにおける免疫療法の効果因子である

Natasja L de Vries1,2, Joris van de Haar3,4,5, Vivien Veninga3,4

  • 1Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.

Nature
|January 11, 2023
PubMed
まとめ

β2-マイクログローブリン (B2M) 不活性化によるDNA不一致修復欠陥 (MMR-d) がんは,免疫チェックポイントブロック (ICB) に反応する. この反応は γδ T 細胞の浸透の増加と関連しており,これらのがんの免疫療法におけるその役割を示唆している.

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