Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Somatosensation01:33

Somatosensation

37.0K
The somatosensory system relays sensory information from the skin, mucous membranes, limbs, and joints. Somatosensation is more familiarly known as the sense of touch. A typical somatosensory pathway includes three types of long neurons: primary, secondary, and tertiary. Primary neurons have cell bodies located near the spinal cord in groups of neurons called dorsal root ganglia. The sensory neurons of ganglia innervate designated areas of skin called dermatomes.
37.0K
Joints01:20

Joints

JointsJoints are the places where two or more bones meet, allowing your body to move in many different ways. Without joints, you wouldn’t be able to bend your knees, wave your hand, or turn your head. There are different types of joints, like hinge joints (knees and elbows), ball-and-socket joints (shoulders and hips), and pivot joints (neck). Joints also include cartilage, ligaments, and fluid that help bones move smoothly and prevent them from grinding together. Learning about joints helps...
Structural Joints: Synovial Joints01:16

Structural Joints: Synovial Joints

3.8K
Synovial joints are the most common type of joint in the body. A key structural characteristic for a synovial joint is the presence of a joint cavity. This fluid-filled space is where the articulating surfaces of the bones contact each other. Also, unlike fibrous or cartilaginous joints, the articulating bone surfaces at a synovial joint are not directly connected to each other with fibrous connective tissue or cartilage. This gives the bones of a synovial joint the ability to move smoothly...
3.8K
Introduction to Special Senses01:26

Introduction to Special Senses

5.9K
Sensory receptors play an integral part in comprehending our external and internal environments. They receive diverse stimuli, converting them into the nervous system's electrochemical signals. This conversion occurs as the stimulus alters the sensory neuron's cell membrane potential, instigating the generation of an action potential. This action potential is subsequently transmitted to the central nervous system (CNS), which integrates with other sensory data or higher cognitive...
5.9K
Development of the Limb Synovial Joints01:07

Development of the Limb Synovial Joints

1.5K
Joints form during embryonic development in conjunction with the formation and growth of the associated bones. The embryonic tissue that gives rise to all bones, cartilage, and connective tissues of the body is called mesenchyme.
The mesenchymal stem cells differentiate into chondrocytes that form the hyaline cartilage, and later the cartilaginous model of the bone. This model further transforms into a bone. This process is known as endochondral ossification.
During development, the limbs...
1.5K
Functional Classification of Joints01:09

Functional Classification of Joints

4.3K
Functional Classification of Joints
The functional classification of joints is determined by the amount of mobility between the adjacent bones. Joints are functionally classified as a synarthrosis or immobile joint, an amphiarthrosis or slightly moveable joint, or as a diarthrosis, a freely moveable joint. Fibrous and cartilaginous joints can be functionally classified as either synarthroses  or amphiarthroses, whereas all synovial joints are classified as diarthroses.
Synarthrosis
An...
4.3K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Cryo-EM reveals a right-handed double-helix dimer architecture of PCDH15.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Risk genes in progressive supranuclear palsy (PSP) affect integrity and function of microtubules.

Frontiers in aging·2026
Same author

Precise Measurement of the Λ-Binding-Energy Difference between _{Λ}^{3}H and _{Λ}^{4}H via Decay-Pion Spectroscopy at MAMI.

Physical review letters·2026
Same author

Cryo-EM reveals a right-handed double-helix dimer architecture of PCDH15 critical for mechanotransduction.

bioRxiv : the preprint server for biology·2026
Same author

Basal progenitors as drivers of neocortical expansion.

Trends in neurosciences·2026
Same author

Syngap1 and the development of murine neocortical progenitor cells.

Nature communications·2025

関連する実験動画

Updated: Aug 14, 2025

A Simple Non-invasive Method for Temporary Knockdown of Upper Limb Proprioception
07:42

A Simple Non-invasive Method for Temporary Knockdown of Upper Limb Proprioception

Published on: March 3, 2018

9.5K

機械感覚と関節の変形

Ulrich Müller1

  • 1Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, MD, USA.

Science (New York, N.Y.)
|January 12, 2023
PubMed
まとめ

感覚神経メカニカセンサの機能障害は 関節収縮につながる. この発見は 関節の硬化と不動性を 引き起こす新しいメカニズムを明らかにしています

科学分野:

  • 神経科学
  • 機械生物学
  • 整形外科

背景:

  • 関節の収縮は 硬直と限られた運動範囲を特徴とし 患者の移動能力と生活の質に大きな影響を及ぼします
  • 関節収縮の根本的なメカニズムは十分に理解されておらず,効果的な治療法の開発を妨げています.
  • 感覚神経は関節機能を調節する役割がありますが,関節の発達への具体的な貢献は不明です.

研究 の 目的:

  • 関節収縮の発達における感覚神経におけるメカノセンサの役割を調査する.
  • 機械センサーによる関節収縮に 関わる特定の分子経路を特定する.

主な方法:

  • センサーニューロンの鍵となるメカノセンサ遺伝子を標的として削除したマウスモデルを使用した.
  • 骨格測定と組織分析を用いて関節の動きと収縮の重さを評価した.
  • 感覚神経と関節組織における下流信号経路を調査した.

主要な成果:

  • 感覚神経に特定のメカノセンサが欠けていたマウスは,関節の収縮が著しく減少した.
  • これらのマウスの関節の繊維症と炎症の減少を示した.
  • 機能的なメカニセンサが欠けていたため,メカニトランスデュークションに関連する下流信号伝達経路が変化した.

さらに関連する動画

Addressing Practical Issues in Atomic Force Microscopy-Based Micro-Indentation on Human Articular Cartilage Explants
08:06

Addressing Practical Issues in Atomic Force Microscopy-Based Micro-Indentation on Human Articular Cartilage Explants

Published on: October 28, 2022

1.1K
Measurement of Vibration Detection Threshold and Tactile Spatial Acuity in Human Subjects
07:32

Measurement of Vibration Detection Threshold and Tactile Spatial Acuity in Human Subjects

Published on: September 1, 2016

12.8K

関連する実験動画

Last Updated: Aug 14, 2025

A Simple Non-invasive Method for Temporary Knockdown of Upper Limb Proprioception
07:42

A Simple Non-invasive Method for Temporary Knockdown of Upper Limb Proprioception

Published on: March 3, 2018

9.5K
Addressing Practical Issues in Atomic Force Microscopy-Based Micro-Indentation on Human Articular Cartilage Explants
08:06

Addressing Practical Issues in Atomic Force Microscopy-Based Micro-Indentation on Human Articular Cartilage Explants

Published on: October 28, 2022

1.1K
Measurement of Vibration Detection Threshold and Tactile Spatial Acuity in Human Subjects
07:32

Measurement of Vibration Detection Threshold and Tactile Spatial Acuity in Human Subjects

Published on: September 1, 2016

12.8K

結論:

  • 感覚ニューロンのメカノセンサは 関節収縮の発達を 制御する重要な要素です
  • これらのメカノセンサをターゲットにすることで 関節収縮の予防や治療に 新しい治療戦略が提供されるかもしれません