寄生虫と宿主間のドーム1-JAK-STAT信号は,ベクトル免疫と発達を統合する
Vipin S Rana1, Chrysoula Kitsou1, Shraboni Dutta1
1Department of Veterinary Medicine, University of Maryland, College Park, MD, USA.
Science (New York, N.Y.)
|January 12, 2023
まとめ
ティックは独特の種間通信経路を利用し,哺乳類のインターフェロン-ガンマ (IFN-γ) を利用して独自のJAK-STAT信号を発信します. 宿主との相互作用に進化的に依存していることを示しています
科学分野:
- 進化生物学
- 分子信号
- 寄生虫学
- 免疫学
背景:
- 祖先からの信号伝達経路は,メタゾアの発達,生理,免疫に不可欠です.
- 宿主と寄生虫の相互作用を理解するには 種間コミュニケーションメカニズムが不可欠です
研究 の 目的:
- Ixodes scapularis 受容体 Dome1 を含む進化的種間通信経路を調査する.
- 宿主由来インターフェロン・ガンマ (IFN-γ) がタチの発達と免疫に果たす役割を明らかにする.
- ドーム1-JAK-STAT経路がイクソードのベクトル能力に与える影響を理解する.
主な方法:
- Ixodes scapularis Dome1受容体の特定と特徴づけ
- 哺乳類のインターフェロン-ガンマ (IFN-γ) との相互作用の分析
- ティックのJAK-STAT経路の活性化に関する研究
- ドーム1-JAK-STAT経路がダニの腸細胞再生,変形,免疫における役割を調べる.
主要な成果:
- Ixodes scapularisのダニ受容体 Dome1は,IFN-γに対する高い親和性を持つ哺乳類のサイトカイン受容体モチーフを獲得した.
- ホスト由来のIFN-γはドーム1経由でイクソデスのJAK- STAT経路を活性化し,血液粉の獲得と発達を加速します.
- Dome1-JAK-STAT経路は,腸細胞増殖,変形 (ヘッジホッグおよびノッチ-デルタネットワーク経由) および抗菌成分を調節し,ベクトル能力に影響を与えます.
結論:
- 種間のシグナル伝達経路が存在し,タケは宿主IFN-γを使用して内部JAK-STAT経路を活性化します.
- この経路はほとんどのイクソディドに保存され,その発達,免疫,変形に不可欠です.
- Ixodes scapularisは哺乳類の宿主への進化的依存を示し,関節足の免疫と発達に影響を与えるクロス種のシグナル伝達によって媒介されます.
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