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Programmed Electrical Stimulation in Mice
Published on: May 26, 2010
ヒトの心室における超高速列車ペースによる総和と抑制
C D Swerdlow1, L B Liem, M R Franz
1Cardiac Arrhythmia Unit, Stanford University Medical Center 94305.
Circulation
|November 1, 1987
まとめ
超高速刺激の列は,刺激の特徴に応じて,心臓を捕まえるか,反応を抑制することができます. この研究では,電車が低電流で有効な耐火期を延長し,高電流では短縮し,阻害は周波数と持続時間とともに増加することを発見しました.
科学分野:
- 電気生理学 電気生理学
- 心臓病学 心臓病学
- 医療機器 医療機器について
背景:
- タキアリズム症は,超高速刺激を用いた早期の単発捕捉によって終結させることができます.
- 刺激列は,後続的な刺激に対する反応を抑制することもできる.
- 列車の特徴を理解することは,抗不律性戦略の最適化に不可欠です.
研究 の 目的:
- 超高速刺激列車によるキャプチャと阻害を左右する要因を決定する.
- 単一のエクストラスティミュール (S2) の強度間隔関係と100Hzの電車を比較する.
- パルス周波数,電車走行時間,プロカイナミドの影響を調査する.
主な方法:
- 29人の患者でS2と100 Hz,100 msecの列車の右心室強度間隔関係を比較した.
- 12人の患者ではパルス周波数 (50〜200Hz),11人の患者ではトレーニング期間 (50〜150msec) が変化した.
- 10人の患者でプロカイナミド (10.1 +/- 2.3マイクログラム/ml) の効果を評価した.
主要な成果:
- 100Hzの電車は,低電流強度 (阻害) で有効耐火期 (ERP) を延長し,高電流強度 (合計) で短縮しました.
- 0.5 mAでは,電車ERPはS2 ERPよりも47 msec長く,16 mAでは12 msec短かった (p < .001).
- 阻害はパルス周波数,電車の持続時間,およびプロカイナミドによって増加し,総和はパルス周波数によってのみ増加した.
結論:
- 刺激列の特徴は,効果的耐火期 (ERP) と機能的耐火期 (FRP) に差異的に影響する.
- 抑制とサマーションは,異なる電気生理学的メカニズムによって媒介されるようです.
- 刺激パラメータの最適化は,タキアリズムを効果的に管理するための鍵です.
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The cardiac action potential process involves a series of phases characterized by the movement of ions across the cardiac cell membranes, leading to the depolarization and repolarization of the cardiac myocytes.
Ionic Basis of Cardiac Action Potentials

