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Author Spotlight: Understanding Adolescent Social Adversity Effects on Neurodevelopment in Mice
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社会的地位の喪失と関連したうつ病のような状態の根底にある神経機構

Zhengxiao Fan1, Jiarui Chang2, Yilan Liang2

  • 1Department of Neurobiology, Affiliated Mental Health Center & Hangzhou Seventh People's Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China; Liangzhu Laboratory, MOE Frontier Science Center for Brain Science and Brain-Machine Integration, State Key Laboratory of Brain-Machine Intelligence, Zhejiang University, Hangzhou 311121, China.

Cell
|January 24, 2023
PubMed
まとめ

ネズミの社会的地位の喪失は,負の報酬予測エラーによってうつ状態を誘発し,側頭前皮質 (LHb) を活性化し,中頭前皮質 (mPFC) を阻害する. ステータスを取り戻すと これらの効果は逆転する.

キーワード:
爆破するうつ病ケタミン横のヘブンヌラ報酬予測のエラー社会的競争社会的階層社会的な地位

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