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Updated: Aug 12, 2025

Sequence-specific Labeling of Nucleic Acids and Proteins with Methyltransferases and Cofactor Analogues
12:07

Sequence-specific Labeling of Nucleic Acids and Proteins with Methyltransferases and Cofactor Analogues

Published on: November 22, 2014

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薬剤分子の末期C-Hメチル化

Edna Mao1, David W C MacMillan1

  • 1Merck Center for Catalysis at Princeton University, Princeton, New Jersey 08544, United States.

Journal of the American Chemical Society
|January 25, 2023
PubMed
まとめ

この研究は,C−H機能化を用いて,メチル基を製薬分子に添加する新しい方法を導入している. このアプローチは,複雑な構造を直接改変することによって,薬物アナログの合成を簡素化します.

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