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Updated: Aug 12, 2025

Rapid Isolation of the Mitoribosome from HEK Cells
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リンソームのmTORC1-TFEB-Rag-Ragulatorメガコンプレックス構造

Zhicheng Cui1,2, Gennaro Napolitano3,4, Mariana E G de Araujo5

  • 1Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA, USA.

Nature
|January 25, 2023
PubMed
まとめ

転写因子EB (TFEB) はmTORC1を通じて細胞機能を制御する. クリオ・エムが 独特の

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Sec61 protein conducting channel
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After folding, the ER assesses the quality of secretory and membrane proteins. The correctly folded proteins are cleared by the calnexin cycle for transport to their final destination, while misfolded proteins are held back in the ER lumen. The ER chaperones attempt to unfold and refold the misfolded proteins but sometimes fail to achieve the correct native conformation. Such terminally misfolded proteins are then exported to the cytosol by ER-associated degradation or ERAD pathway for...
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