血管内ナビゲーションのための液体磁気ロボットとしての水不溶性コアセルバート

Pengchao Zhao^1,2,3, Fuyang Qu², Hao Fu¹

¹School of Biomedical Sciences and Engineering, Guangzhou International Campus, South China University of Technology, Guangzhou 511442, P. R. China.

Journal of the American Chemical Society

|February 2, 2023

まとめ

研究者はコアセルバットから新しい磁気液体ロボットを開発しましたこの超柔らかいロボットは毛細血管のような狭い空間に移動しバイオメディカルアプリケーションの高度な機能を備えています

科学分野:

バイオメディカルエンジニアリング
材料科学
ロボット

背景:

現在の柔らかいロボット (弾性体,水素ゲル) は,体内の毛細血管ナビゲーションに必要な極端な変形性と適応性に苦戦しています.
超柔らかいロボットを開発するには変形しやすく反応しやすく適応性のある材料が必要です

研究の目的:

マグネティックに動かし,水に混じらないコアサーバット液体ロボットを設計する
現行の柔らかいポリマー材料の限界を克服するために in vivo アプリケーション.

主な方法:

磁気コアシェルナノ粒子をMAWIコアセルバートに組み立てました.
pHと塩分濃度が異なる状態で安定性をテストした.
評価された貨物放出,毛細血管ネットワークのナビゲーション,および体内の血管内標的.

主要な成果:

MAWIコアサーバット液体ロボットは,異なるpHと塩分条件で安定性を示しました.
数秒で人工毛細血管ネットワークに突入した
外部磁場を使用して,体内での標的型血管内投与を達成した.
生物分解性や生物互換性を示しました

結論:

高性能な超柔らかいロボットの新しい設計戦略を提案しています
この技術は生物医学における現在の弾性体やヒドロゲルベースのソフトロボットを上回る要求の高い作業をこなすことができます
医療用超柔らかいロボットの重要な進歩です

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